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Dear Clinic · Procedure Comparison · Skin Boosters
PDRN vs PDLLA

Rejuran vs Juvelook

Two of Korea's most-asked-for regenerative injectables — one built on salmon-DNA PDRN, the other on collagen-stimulating PDLLA. They improve skin in different ways, and the right one depends on what your skin actually needs.

Both in-house at Dear Diagnosis-led recommendation Open 365 days
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Short Answer

Rejuran or Juvelook — which?

Rejuran (Rejuran Healer) is a PDRN booster — polydeoxyribonucleotide derived from salmon DNA — that focuses on repairing and revitalizing skin quality: hydration, elasticity and fine texture. Juvelook is a PDLLA booster (poly-D,L-lactic acid combined with HA) that gradually stimulates your own collagen for a firmer, subtly restored look over time. If your priority is skin healing, glow and resilience, Rejuran fits; if it's gradual collagen volume and firmness, Juvelook fits. Many treatment plans use them for complementary goals.

The simplest way to hold the difference: Rejuran repairs, Juvelook rebuilds. PDRN acts on skin regeneration, calming and revitalizing the dermis. PDLLA breaks down slowly in the skin and prompts a gradual collagen-building response behind it. Neither one volumizes the way a structural filler does. Juvelook is the name most people arrive already asking for by brand; the EVE 3D reading is what settles whether their skin wants repair first, collagen first, or a course of both.

Side by Side

Rejuran vs Juvelook, compared

Active ingredient, unit of sale, target and published rate, set out line by line.

  Rejuran Healer Juvelook
Active ingredient PDRN (polydeoxyribonucleotide, salmon DNA) PDLLA (poly-D,L-lactic acid) + HA
Primary action Skin repair & revitalization Gradual collagen stimulation
Best for Texture, elasticity, hydration, dull/tired skin Firmness, subtle restoration, skin quality over time
Result timeline Progressive over a course of sessions Gradual, long-lasting as collagen builds
Typical course A planned course; session count and interval set at diagnosis Planned per skin; effect matures over months
Category Regenerative booster (not a volumizer) Collagen-stimulating booster
Lines stocked Rejuran Healer · Rejuran HB · Rejuran Eye Juvelook Volume — standard and specialty-area dosing
At Dear, from ₩300,000 (≈ $215) / 2cc ₩100,000 (≈ $70) / 1cc

Prices shown are per-unit published rates, identical for locals and international visitors; your full course and total are planned and approved at consultation before treatment. Number of sessions varies by skin condition and goal.

By Your Case

When Rejuran fits, when Juvelook fits

Three readings our directors read off the EVE scan, and the product each one points at.

CASE 01 — REJURAN

Rough surface, low elasticity

Dullness, dehydration, a surface that has stopped bouncing back. PDRN is the repair-side molecule, which puts Rejuran Healer here at ₩300,000 (≈ $215) per 2cc. Thin under-eye skin is treated from the HB and Eye lines instead, ₩400,000 (≈ $285) per 2cc.

CASE 02 — JUVELOOK

Firmness that has to be grown

Juvelook is PDLLA carried in HA. It dissolves slowly and your own collagen answers behind it, so this one is dosed in cc and read back in months — ₩100,000 (≈ $70) per 1cc.

CASE 03 — BOTH

Repair the base, then rebuild

Some scans show both things at once: poor skin quality and genuine slackness. Then the order is the decision. Rejuran goes first to settle the base, Juvelook follows to build on it, and the gap between the two courses is written into the plan so your skin is never carrying both at the same time. Both products are stocked here, so the sequence costs nothing to arrange.

Main reception with stone counter and bouclé armchairs at Dear Clinic Cheongdam
Main reception with stone counter and bouclé armchairs at Dear Clinic Cheongdam
Reception seen from the opposite angle with the arc floor lamp at Dear Clinic Cheongdam
Reception seen from the opposite angle with the arc floor lamp at Dear Clinic Cheongdam
Before & After

Real Dear cases, side by side

Unretouched cases treated at Dear Clinic, shown with consent. Each image shows only its own treatment. Individual results vary.

Rejuran skin booster before and after — same patient, calmer, smoother skin texture, Dear Clinic case
Rejuran · before / after — same person, same conditions, improved skin quality
Juvelook collagen stimulator before and after — same patient, firmer, more restored skin, Dear Clinic case
Juvelook · before / after — same person, same conditions, firmer, restored skin

All photos are unretouched before/after cases of the same person under the same conditions, treated at Dear Clinic and shown with consent. Each photo shows only the treatment it is labelled with. Individual results may vary; no specific outcome is implied or promised.

The Combination

Why they can work together

Rejuran and Juvelook aren't competitors so much as two tools with different jobs. A common way to think about staging them:

Rejuran's PDRN focuses on repairing and revitalizing skin quality — texture, elasticity, hydration.
Juvelook's PDLLA focuses on building collagen for firmness that develops gradually.
Repairing the skin base first can create healthier ground for collagen stimulation to build on.
Intervals are planned so the skin isn't over-treated — regenerative boosters work best on a considered schedule.

Both products sit in the same fridge here, alongside Sculptra, Radiesse, SkinVive and Laetigen. That means the plan can read Rejuran alone, Juvelook alone, the two in sequence, or none of them. Whichever it reads, it is written down and priced before a vial is opened.

Illustrative image — revitalized, firm skin quality from a regenerative booster plan (not a patient result)
The goal of a booster plan — healthier skin quality plus gradual firmness. (Illustrative image; no patient photograph is shown here.)
Dear, Knowhow

How the choice between PDRN and PDLLA gets made here

01 — THE FULL ARSENAL

The shelf holds more than these two

Sculptra is PLLA by the vial; Radiesse is CaHA; Laetigen is sold in 2cc. Those stand beside Rejuran and Juvelook in the same room, so a scan that points away from both of the products on this page still ends with something specific on the chart.

02 — DIAGNOSIS FIRST

What the five light sources read

EVE Muse captures your face in 3D under five light sources, and texture, elasticity and hydration come back as separate readings. That separation is the whole point of scanning before prescribing: a complexion can read badly on hydration and still hold perfectly good elasticity, and that combination points at PDRN. The reading is taken before either brand is named out loud.

03 — DIRECTOR-PERFORMED

Depth, dose and interval, all recorded

Three variables decide what a regenerative booster does: how deep the needle sits, how much goes in per point, and how long you wait before the next one. Your director places every point personally, sets all three numbers and writes them down, so session four builds on session three.

In the clinic

The devices and hands behind this treatment

Rejuran carton standing upright, three-quarter view
Rejuran carton standing upright, three-quarter view
Private recovery room with its own washbasin at Dear Clinic Cheongdam
Private recovery room with its own washbasin at Dear Clinic Cheongdam
Juvelook vial with a blue cap, a PLA and hyaluronic acid hybrid injectable, on a transparent background
Juvelook vial with a blue cap, a PLA and hyaluronic acid hybrid injectable, on a transparent background
When we say no

When a booster is the wrong prescription

Not every dull or slack-looking complexion needs a needle. Descent at the deeper layer is a lifting problem and no booster will lift it; hollowing in one specific area is a filler problem. When the scan reads either of those we do not recommend Rejuran or Juvelook, and the treatment that does fit is priced for you in the same appointment. Both products also carry the ordinary risks of an injection, worth naming here: small bumps at the entry points, redness, swelling and occasional bruising, most of it gone inside a day or two. A lump you can still feel by the follow-up call is looked at, and skin that is mid-breakout has its injection date moved.
01
Skin texture & glow
02
Elasticity & hydration
03
Gradual firmness
04
Natural, progressive change

Outcomes and suitability vary by individual and are assessed at your in-person diagnosis.

Ring-shaped wall light in a curved corridor at Dear Clinic Cheongdam
Ring-shaped wall light in a curved corridor at Dear Clinic Cheongdam
EVE Muse AI analysis screen showing multi-angle facial capture
EVE Muse AI analysis screen showing multi-angle facial capture
Caution

After a Rejuran or Juvelook session

Juvelook has the stricter aftercare sheet of the two, so the timings below follow it.

Small bumps at the entry points and a little redness are normal on day one, and settle within a day or two.
Wash and make up gently for the first 48 hours. Makeup on the day itself is fine; a scrubbing motion is not.
No scrubs, no exfoliating peels and no acid peels for a full week after the session.
Alcohol and cigarettes both raise the inflammation risk at fresh injection points, so give them about a week.
Saunas and hot baths wait a few days, and anything still unsettled at the follow-up call gets seen.
Medical Team

Five doctors, one standard

Director-performed treatment is a Dear promise — your procedure is planned and performed by the doctors below.

Dr. Jemin Kim — Medical Director and Founder, Dear Clinic
Dr. Jemin Kim
Yonsei University College of Medicine
Medical Director · Founder
Dr. Sanghyun Lee — Director, Dear Clinic
Dr. Sanghyun Lee
Seoul National University College of Medicine
Director
Board-certified · Family Medicine
Dr. Seonhaeng Lee — Director of Aesthetic Medicine, Dear Clinic
Dr. Seonhaeng Lee
Chosun University College of Medicine · Residency, Samsung Medical Center
Director, Aesthetic Medicine
Dr. Daeun Jung — Director, Dear Clinic
Dr. Daeun Jung
Ajou University College of Medicine
Director
Board-certified · Family Medicine
Dr. Woojae Jung — Director of Aesthetic Medicine, Dear Clinic
Dr. Woojae Jung
Seoul National University — B.S. in Medicine
Director, Aesthetic Medicine
Patient Reviews

What our patients say

Real verified reviews from our Google Business Profile.

4.9★★★★★ 293 Google Reviews
FAQ

Rejuran vs Juvelook, answered

What's the main difference between Rejuran and Juvelook?
Rejuran is built on PDRN — polydeoxyribonucleotide from salmon DNA — and works on skin quality: texture, elasticity, hydration. Juvelook is PDLLA (poly-D,L-lactic acid) carried in HA, and it dissolves slowly so that your own collagen builds behind it. Different molecules, different jobs, different units of sale: Rejuran is priced in 2cc, Juvelook in 1cc.
Is Rejuran or Juvelook better for glass skin and glow?
For the healthier, more revitalized complexion most people mean by glass skin, Rejuran's PDRN action often fits, since texture, hydration and elasticity are exactly what it works on. Juvelook leans toward firmness that arrives over months. Your EVE 3D reading separates those two readings, which is why it is taken before the choice is made.
Which is better for firmness and gradual restoration?
Juvelook is the collagen-stimulating option: its PDLLA prompts your own collagen to build gradually for a firmer, subtly restored look that develops over months. Rejuran can support elasticity through skin repair, but if firmness is the primary goal, PDLLA stimulation is usually the more direct route. Both are assessed against your diagnosis.
Can I get Rejuran and Juvelook together?
Yes — and the usual order is Rejuran first to settle skin quality, then Juvelook to build collagen on the repaired base. Intervals are planned so your skin is not carrying both courses at once. Your director sets the combination, the cc and the schedule from your diagnosis; there is no fixed package to buy into.
How many sessions of each do I need?
Both are planned as a course, and the count is set at your diagnosis. Rejuran is dosed in 2cc units and Juvelook in 1cc, so the total is arithmetic you can check in the consulting room before anything is opened. No session number is published on this page, because the real figure follows what the scan reads on your face.
How much do Rejuran and Juvelook cost in Seoul?
At Dear Clinic, Rejuran Healer is ₩300,000 (≈ $215) for 2cc, the Rejuran HB and Eye lines are ₩400,000 (≈ $285) for 2cc, and Juvelook Volume is ₩100,000 (≈ $70) per 1cc, or ₩200,000 (≈ $145) per 1cc in specialty areas. These are published rates, identical for Korean and international patients, and your full plan is approved before treatment.
Are these fillers?
Neither one volumizes the way a structural filler does. Rejuran works on skin repair through PDRN; Juvelook stimulates collagen through PDLLA. Where the concern is real hollowing in one area, a hyaluronic acid filler is the correct prescription and we will say so at the diagnosis, then price that instead.
Is there downtime after Rejuran or Juvelook?
Downtime is minimal for both. Small injection bumps, mild redness or slight swelling at the injection points can appear and usually settle within a day or two. Avoid saunas, alcohol and aggressive skincare briefly. Most patients return to normal plans the same day.
Do the results last?
Rejuran's revitalizing effect builds progressively over a course and is maintained with periodic sessions, while Juvelook's collagen-driven firmness develops gradually and tends to be long-lasting as new collagen forms. Duration varies with individual skin, age and lifestyle, and is discussed as part of your plan.
Can the first Rejuran or Juvelook session run the same day as my consultation?
Usually. The EVE 3D capture and the doctor's reading of it take about 30 minutes, then topical numbing needs its own waiting time before any needle goes in, so allow roughly ninety minutes end to end. Because the aftercare sheet asks you to skip scrubs and peels for a week afterwards, it is worth booking early in a Seoul trip. We open every day of the year, Sundays and public holidays included.
Do Rejuran and Juvelook cost more for a visitor from abroad?
No. ₩300,000 (≈ $215) per 2cc and ₩100,000 (≈ $70) per 1cc are the same lines on the same published list a Korean patient is quoted from. You settle in KRW; the dollar figure on this page is a courtesy conversion. Since a course is dosed in cc, the total follows from how many units your plan calls for, which is agreed at the scan.
Which of the two is better for enlarged pores and old acne scarring?
Juvelook's published indications include pores, fine wrinkles and skin texture, so a pore-led concern is usually where it is considered first. Rejuran is aimed at repair and elasticity, and can be the better opening move where the skin is also thin and irritable. Deep, indented acne scars are a different problem from either, and are answered with resurfacing or subcision instead — the scan will show which of the three you are actually looking at.
Consultation

Ask which booster fits your skin

Your questions, answered in English within one business day.

Scientific Evidence

Science behind PDRN & PDLLA — peer-reviewed references

Comparing a PDRN booster with a PDLLA collagen stimulator is grounded in peer-reviewed literature on each mechanism — tissue-repair activity of polydeoxyribonucleotide, and collagen stimulation by poly-lactic-acid injectables. The studies below inform how our directors match a booster to your skin after your EVE 3D + AI diagnosis.

Note that the fourth paper below compares poly-L-lactic acid with poly-D,L-lactic acid directly, which is the distinction between Sculptra and Juvelook, and is the reason the two are not interchangeable on a chart. Every reference carries a resolvable DOI, so the original is there to read. Individual results may vary and suitability is assessed in person.

  1. Guizzardi S, et al. Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: A new proposal for bone tissue repair. Life Sciences. 2003. doi:10.1016/s0024-3205(03)00547-2
  2. Hong J, et al. Therapeutic Performance of Needle Injection Versus Needle-Free Jet Injector System for Polynucleotide Filler in Skin Rejuvenation. Journal of Cosmetic Dermatology. 2024. doi:10.1111/jocd.16595
  3. Fitzgerald R, et al. Facial volume restoration of the aging face with poly-l-lactic acid. Dermatologic Therapy. 2011. doi:10.1111/j.1529-8019.2010.01375.x
  4. Lin J, et al. Early-stage volume effect difference between injectable poly-l-lactic acid and injectable poly-d,l-lactic acid. Journal of Cosmetic Dermatology. 2022. doi:10.1111/jocd.15595

References are provided for information — outcomes vary by individual and are assessed at your diagnosis.

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