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Dear Clinic · Procedure Information · Skin Boosters
PDRN Polynucleotide Booster

Rejuran Healer

The salmon-DNA injectable Korea is known for — a polynucleotide booster aimed at the condition of your skin itself, prescribed only when your diagnosis says skin quality is the real problem.

PDRN · polynucleotide formula ₩300,000 (≈ $215) / 2 cc Open 365 days
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About

What is Rejuran Healer?

Rejuran Healer is an injectable skin booster made by PharmaResearch whose active ingredient is PDRN — polydeoxyribonucleotide, a purified polynucleotide fraction derived from salmon DNA. It adds no volume. It is delivered into the skin itself in fine deposits to support repair and revitalisation, which is why it sits with the regenerative boosters on our shelf and nowhere near the fillers.

Most people searching for it in English arrive by one of three names: Rejuran, the salmon DNA injection, or simply a PDRN injection. All three point at one idea: treating the quality of the skin instead of its shape. What the injection targets is the tissue carrying resilience, hydration and fine surface texture. It will not make a face look fuller, and it will not raise a jawline.

That distinction matters more than it sounds. A booster placed into skin that has genuinely descended will not lift it, and a booster placed into skin that needs structural support will not build it. Rejuran belongs to a specific problem — and at Dear the EVE 3D reading decides whether that problem is yours before a syringe is opened.

Rejuran carton in black and silver shown at an angle
Every Rejuran plan starts here — with the diagnosis on screen, before any product is discussed.
Treatment Areas

Where Rejuran is delivered

The injection map is drawn from your EVE 3D reading — skin thickness, texture breakdown and the zones where resilience has dropped most.

01

Full face

The standard request: overall skin condition — roughness, dullness, loss of bounce — addressed across the face in an even, mapped pattern.

02

Under-eye area

Thin, crepey, tired-reading skin beneath the eye is delicate work with its own product line and its own price, planned separately from the face.

03

Cheeks & textured zones

Areas where surface irregularity and enlarged pores dominate, treated with denser placement where the reading shows the most breakdown.

04

Around the mouth and forehead

Fine surface lines that live in the skin itself. Where the same line is muscle-driven, a relaxant is the better answer and PDRN is the wrong one.

VIP single treatment room with a blue velvet armchair and gold side table at Dear Clinic Cheongdam
VIP single treatment room with a blue velvet armchair and gold side table at Dear Clinic Cheongdam
Procedure room with a powered treatment table, IV stand and infusion pump at Dear Clinic Cheongdam
Procedure room with a powered treatment table, IV stand and infusion pump at Dear Clinic Cheongdam
The Rejuran Line

Healer, HB and Eye — three jobs at Dear

Rejuran is a family of three products. Choosing between them is a clinical decision, and it changes both the technique and the price on your quote.

LINE 01

Rejuran Healer

The original polynucleotide formula and the one most people mean by “Rejuran”. Dosed in 2 cc units at Dear and used for general skin condition across the face.

LINE 02

Rejuran HB

The hydro-balance formulation, which pairs the polynucleotide component with hyaluronic acid. Selected when hydration and immediate surface smoothness are weighted more heavily in the plan.

LINE 03

Rejuran Eye

Formulated for the thin, mobile skin under the eye, where placement has to be shallower and far more precise. Priced with HB at the dedicated rate.

Diagnosis decides which line you receive; booking does not. Arrive asking for one, and if your skin reads better suited to another — or to no booster at all — your director says so before a syringe is prepared. Individual responses differ, and the plan is written to your face.

Procedure room at Dear Clinic with radiofrequency and ultrasound body-contouring systems
Procedure room at Dear Clinic with radiofrequency and ultrasound body-contouring systems
Entrance of Dear Clinic in Cheongdam, Gangnam, Seoul, with the clinic hours shown in English on the glass door
Entrance of Dear Clinic in Cheongdam, Gangnam, Seoul, with the clinic hours shown in English on the glass door
Before & After

Real Dear Rejuran cases

Unretouched cases treated at Dear Clinic, shown with consent.

Rejuran before and after — improved skin condition and smoother surface, Dear Clinic case
Rejuran · before / after — improved skin condition
Rejuran before and after — more even, revitalised skin texture, Dear Clinic case
Rejuran · more even, revitalised texture

All photos are unretouched cases of the same person under the same conditions, treated at Dear Clinic. Each photo shows only the treatment it is labelled with. Individual results may vary.

Dear, Knowhow

How the Rejuran line is chosen here

01 — THE FULL ARSENAL

All three Rejuran lines on the shelf

Healer, HB and Eye are stocked here, next to the PDLLA, PLLA, CaHA and HA boosters and a room away from the lifting platforms. Healer is ₩300,000 (≈ $215) per 2 cc and the HB and Eye lines ₩400,000 (≈ $285) per 2 cc, published beside every product we might send you to instead.

02 — DIAGNOSIS FIRST

What five light sources separate

The EVE Muse system captures your face in 3D under five light sources with AI analysis. Whether your complaint is genuinely skin condition, or laxity wearing a skin-condition disguise, is settled there on screen with you looking at it. The two look identical in a bathroom mirror.

03 — DIRECTOR-PERFORMED

Why PDRN placement is millimetre work

A polynucleotide booster lives or dies on placement: too shallow and you get lumps, too sparse and you get nothing. Your session is performed by our directors, working to a minimum effective dose per zone and stopping when the mapped area is covered, whatever is left in the syringe. Bruising at the entry points and a day or two of small raised bumps are the ordinary costs of doing it properly.

EVE Muse AI skin analysis system used before planning a Rejuran Healer course
EVE Muse AI skin analysis — 3D capture and five-light-source reading, before any booster is chosen.
Treatment room at Dear Clinic where Rejuran Healer injections are performed
The same director who designs your map performs the injection — and reviews it afterwards.
In the clinic

The devices and hands behind this treatment

Rejuran pre-filled syringe with a dark grey plunger, on a transparent background
Rejuran pre-filled syringe with a dark grey plunger, on a transparent background
Rejuran carton standing upright, three-quarter view
Rejuran carton standing upright, three-quarter view
Rejuran Rejuvenation Club VVIP membership plaque issued to Dear Clinic
Rejuran Rejuvenation Club VVIP membership plaque issued to Dear Clinic
Before You Book

How to read Rejuran reviews from Korea

There is a great deal written about this treatment online. Here is what is worth weighing before you form an expectation.

Check what problem the writer had. An account describing dull, dehydrated, rough skin is not comparable to one describing a sagging jawline. A repair-focused booster is being judged on two different jobs, and only one of them is the job it was designed for.
Check the product line. Healer, HB and Eye behave differently and are placed differently. A great deal of the disagreement you will read online is simply people comparing different products under one brand name.
Check the timeline being described. A regenerative booster is not judged on day one. Impressions written the morning after a session describe injection marks. They describe nothing about how the skin repaired.
Check whether a diagnosis happened at all. Where no imaging preceded the course, the account is describing a booking process. It is not evidence about PDRN.
Discount anything that promises a fixed outcome. Skin varies with age, condition, medication and habit. No one can name your result before seeing your skin; a number quoted over a message is a sales target.

Our own position is deliberately plain. You see your EVE reading on screen, you hear what a polynucleotide booster can and cannot address on your face, and the session count and the total go in front of you before anything starts. Outcomes still vary between individuals, because skin does. The plan and the price are the two things that stay fixed once you have agreed them.

Pricing

How much does Rejuran
cost in Seoul?

At Dear Clinic in Cheongdam, Rejuran Healer is ₩300,000 (≈ $215) for 2 cc, and the HB and Eye lines are ₩400,000 (≈ $285) for 2 cc. These are published rates, identical for locals and for international visitors. Which line and how many sessions your skin actually needs is decided at your diagnosis, and the total is agreed with you before treatment begins.
ItemIncludesPrice
Rejuran Healer — 2 ccPolynucleotide booster, mapped placement across planned zones₩300,000 (≈ $215)
Rejuran HB / Eye — 2 ccHydro-balance and under-eye lines, placed at their own depth₩400,000 (≈ $285)
Every planEVE 3D & AI diagnosis · director consultation · aftercare follow-upincluded

Published rates as of September 2026. One price list applies to everyone — KRW is what you pay, USD is shown for reference, and there is no visitor surcharge and no add-on quoted on the day of treatment. A booster is usually planned as a short series, so the likely shape of that series is set out at consultation and you decide with the full figure in view. The units matter when you compare: Rejuran here is quoted per 2 cc, while several other boosters on our list are quoted per 1 cc.

Caution

After your Rejuran session

Small raised points at the injection sites are normal immediately afterwards and settle on their own.
Keep cleansing and make-up gentle for a day or two — as little friction on the skin as possible.
Mild redness or a temporary blemish can appear; it usually resolves without intervention.
Avoid scrubs, exfoliating routines and peeling procedures for about a week.
Hold off on alcohol, smoking and saunas for roughly a week, since all three raise the risk of inflammation while the skin is responding.
If anything persists or concerns you, contact us — the aftercare follow-up call is part of the treatment.
Medical Team

Five doctors, one standard

Director-performed treatment is a Dear promise — your procedure is planned and performed by the doctors below.

Dr. Jemin Kim — Medical Director and Founder, Dear Clinic
Dr. Jemin Kim
Yonsei University College of Medicine
Medical Director · Founder
Dr. Sanghyun Lee — Director, Dear Clinic
Dr. Sanghyun Lee
Seoul National University College of Medicine
Director
Board-certified · Family Medicine
Dr. Seonhaeng Lee — Director of Aesthetic Medicine, Dear Clinic
Dr. Seonhaeng Lee
Chosun University College of Medicine · Residency, Samsung Medical Center
Director, Aesthetic Medicine
Dr. Daeun Jung — Director, Dear Clinic
Dr. Daeun Jung
Ajou University College of Medicine
Director
Board-certified · Family Medicine
Dr. Woojae Jung — Director of Aesthetic Medicine, Dear Clinic
Dr. Woojae Jung
Seoul National University — B.S. in Medicine
Director, Aesthetic Medicine
Patient Reviews

What our patients say

Real verified reviews from our Google Business Profile.

4.9★★★★★ 293 Google Reviews
FAQ

Rejuran Healer, answered

Is Rejuran worth it?
If your complaint is the condition of the skin — dullness, rough texture, a dehydrated and unresilient feel — then a polynucleotide booster works at the level where that complaint lives, and it is a reasonable place to start. If what actually bothers you is a jawline that has dropped or a hollow that needs structure, no booster will resolve it and we will say so at diagnosis. Your EVE reading answers that question; a review written about someone else's face cannot.
How much does Rejuran cost in Seoul?
At Dear Clinic, Rejuran Healer is ₩300,000 (≈ $215) for 2 cc, and the HB and Eye lines are ₩400,000 (≈ $285) for 2 cc. Those published rates apply identically to locals and to international visitors, with KRW as the payable amount and USD shown for reference. Which line suits you, and how many sessions the plan involves, is decided at consultation and agreed before treatment.
Why is Rejuran quoted per 2 cc when other boosters are quoted per 1 cc?
Because that is the unit the product comes in and the unit our price list uses for it. Rejuran Healer is ₩300,000 (≈ $215) for 2 cc and the HB and Eye lines are ₩400,000 (≈ $285) for 2 cc, while a PDLLA collagen booster on the same list is quoted per 1 cc. Comparing the two headline numbers side by side therefore tells you very little. Ask instead for the total of the plan your director writes.
Is Rejuran the same thing as a salmon DNA injection?
Yes — that is the same treatment under an everyday name. The active ingredient is PDRN, short for polydeoxyribonucleotide, a purified polynucleotide fraction obtained from salmon DNA. English-language searches for salmon DNA injection, PDRN injection and Rejuran all lead to the same category of regenerative booster; Rejuran is simply the brand from PharmaResearch that made it widely known.
What is the difference between Rejuran Healer, HB and Eye?
Healer is the original polynucleotide formulation, used for general skin condition. HB adds hyaluronic acid for a hydro-balance emphasis. Eye is formulated for the thin, highly mobile skin beneath the eye and demands shallower, more exact placement. At Dear, Healer is priced separately from the HB and Eye lines, and which one you receive is a clinical decision taken at diagnosis.
Is Rejuran a filler?
No. A filler is chosen for its ability to hold shape and occupy space, while Rejuran is placed into the skin to work on its condition. Contour is outside its job description. If your face has lost genuine volume in a defined area, a filler is what we recommend and quote. The two products sometimes appear in one overall plan, and even then they are answering different questions.
How many sessions will I need?
Regenerative boosters are normally planned as a short series spaced a few weeks apart, because the skin responds progressively. The precise number depends on your starting condition and your goal, and Dear does not sell a fixed package in advance. Your director sets out the likely shape of the series at consultation, and each subsequent session is confirmed against what the last one produced. We publish no standard course length here, because we have not been given one to publish.
Does it hurt, and what are the bumps afterwards?
It is a series of fine injections into the skin, so you feel it more than a surface treatment. Topical numbing goes on beforehand and most people describe the session as brief and manageable, with the under-eye area the most sensitive part — one reason that area is planned and dosed on its own. Afterwards, small raised points sit at the injection sites; that is the product in the skin and they settle by themselves. Mild redness, slight swelling and occasional bruising can keep them company for a day or two, and most people carry on the same day while keeping skincare gentle and leaving scrubs, peels, alcohol and saunas alone for about a week.
When will I see the effect, and how long does it last?
Nothing meaningful shows on the first day. The change follows the pace of skin repair, building across the series instead of arriving after one visit, and it is maintained with periodic sessions afterwards. How long it holds varies with age, skin condition and lifestyle, so we assess where you are at review instead of quoting a fixed duration in advance. Any clinic naming a precise month count from a photograph is guessing.
Can I have Rejuran under my eyes?
The Eye line exists for exactly that, and it is one of the more common requests we receive from international visitors. The skin there is thin and constantly moving, so placement is shallower and considerably more exacting, and it is quoted at the HB and Eye rate of ₩400,000 (≈ $285) for 2 cc. Suitability is assessed in person, since not every under-eye complaint is a skin-quality problem: hollowing and pigment both read as shadow and neither answers to PDRN.
Who should not have Rejuran?
Injectables are not appropriate during pregnancy or breastfeeding, where there is active infection or inflammation at the treatment site, or where a sensitivity to a product component is known. A fish-derived ingredient also makes your allergy history relevant. Current medication, autoimmune conditions and previous injectable treatments are all reviewed at consultation, and we do not proceed if the treatment is unsuitable for you.
I am in Seoul for a week — how much of a Rejuran course fits?
Realistically, the first session and the scan that plans it. The EVE 3D capture and director consultation happen in the first part of the appointment, and where a polynucleotide booster is confirmed as suitable, treatment follows the same day. The rest of the series is spaced by weeks, so it continues on a later visit or with a clinic at home, and your reading stays on file either way. Send the consultation form below with your arrival and departure dates: we reply in English within one business day, hold the slot without a deposit, and charge the same published rate as everyone else. Dear Clinic is open 365 days a year, including Sundays and public holidays.
Consultation

Ask about Rejuran Healer

Your questions, answered in English within one business day.

Scientific Evidence

Science behind PDRN and polynucleotides — peer-reviewed references

Polydeoxyribonucleotide has been studied across several tissue types since long before it became a familiar name in aesthetics. The references below span its early laboratory characterisation, a recent overview of where the research stands, and a clinical comparison of two ways of delivering a polynucleotide product into skin.

We list them so you can go to the primary sources instead of taking a clinic's word for the mechanism. Each carries a verifiable DOI from an indexed journal. None of them is a statement about your face: what applies to you is settled at your EVE 3D diagnosis, and individual responses differ.

  1. Guizzardi S et al. Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: A new proposal for bone tissue repair. Life Sciences. 2003. doi:10.1016/s0024-3205(03)00547-2
  2. Kim J. Polydeoxyribonucleotide (PDRN) - Established Efficacy and Emerging Directions in Research and Development -. Journal of Biotechnology and Bioindustry. 2025. doi:10.37503/jbb.2025.13.14
  3. Hong J et al. Therapeutic Performance of Needle Injection Versus Needle‐Free Jet Injector System for Polynucleotide Filler in Skin Rejuvenation. Journal of Cosmetic Dermatology. 2024. doi:10.1111/jocd.16595

References are provided for information — outcomes vary by individual and are assessed at your diagnosis.

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